For vaginal cancers, treatment is based on the extent of disease and involvement of adjacent structures and the general health of the patient. Treatment recommendations include external beam irradiation with or without chemotherapy and brachytherapy. Some early cases with disease limited to the upper one-third of the vagina may be treated with surgical excision/resection with or without brachytherapy.
In general, it is recommended to treat with definitive external beam irradiation and BT for most tumors.
Vulva cancers are usually treated with wide local resection followed by consideration of adjuvant radiation or chemoradiation based on operative findings and surgical pathology reports. In cases where there is no significant reduction of the tumor, additional external beam irradiation or brachytherapy may be indicated.